Objective: Study on whether the symptoms of acral paresthesia in patients with vitamin D deficiency (VDD) could be alleviated by vitamin D (VD) supplementation.
Methods: We retrospectively reviewed the charts of patients with paresthesia and isolated VDD (iVDD)for a 3-year period. Patients with identifiable etiologies for neuropathy or comorbidities in history as an established risk factor for neuropathy, or without an electrophysiology study, were excluded. Symptoms and serum 25(OH)D3 levels prior to and post-VD supplementation were analyzed.
Results: Of 78 patients with VDD and acral paresthesia, 10 patients (age: 46.7±12.8 years) with iVDD [25(OH)D3, 20.9±5.4 ng/mL] were studied. Supplementation of VD increased the serum VD level (28.6±9.1 ng/mL, p=0.03) and partially ameliorated symptoms in 6/10 (60%) of patients in 10.3±7.1 months.
Conclusions: VDD may contribute to developing, or potentiating the severity of, symptoms in patients with acral paresthesia as a potentially risk factor for peripheral neuropathy, particularly for patients with acral paresthesia.

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