Indomethacin-Responsive Headaches in Pediatric Age: Nosographic Aspects and Limitations on the use of Indomethacin in Pediatric Population

Luca Maria Messina, Edvige Correnti, Flavia Drago, Giorgia Plicato, Lucia Rocchitelli, Francesca Vanadia, Filippo Brighina and Vincenzo Raieli
 

Abstract

Headaches are a common problem in children and adolescents. Indomethacin-responsive headaches are a poorly known and rare group of primary headaches, with few cases during childhood. These include a heterogeneous group of disorders characterized by their response to indomethacin, a non-steroidal anti-inflammatory drug which inhibits cyclooxygenase and therefore the production of prostaglandins. Indomethacin-responsive headaches include Valsalva-induced headaches (cough, exercise or sex headache), primary stabbing headache, hypnic headache and the trigeminal autonomic cephalalgias (TACs) [a group of primary headache disorders that includes cluster headache (CH), paroxysmal hemicrania (PH), hemicrania continua (HC) and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing/cranial autonomic features (SUNCT/SUNA)]. It seems useful to make a review of the literature about these disorders.

Published on: December 04, 2018
doi: 10.17756/jnen.2018-041
Citation: Messina LM, Correnti E, Drago F, Plicato G, Rocchitelli L, et al. 2018. Indomethacin-
Responsive Headaches in Pediatric Age: Nosographic Aspects and Limitations on the use of Indomethacin in Pediatric Population. J Neurol Exp Neurosci 4(2): 36-41.
 
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