Lymphocytes T Helper 17 in Multiple Sclerosis: Regulation by Intestinal Microbiota

Bruno Bagatin de Souza Moreira, André Eduardo de Almeida Franzoi, Marcus Vinícius Magno Gonçalves, Osvaldo José Moreira do Nascimento, Jefferson Becker and Jean Pierre Schatzmann Peron


Multiple sclerosis (MS) is an autoimmune disease with significant damage to the central nervous system (CNS). Despite many studies, it is not clear what triggers the mechanism for the disease to manifest or to exacerbate itself. There is a central role of T helper 17 (Th17) lymphocytes in the proinflammatory cascade of MS. Recent scientific studies have been evaluating the influence of intestinal dysbiosis in MS. However, there are no studies that correlate the role of intestinal dysbiosis on Th17 lymphocytes in MS patients.
This review focused on understanding the role of these lymphocytes and their relationships with MS. For this, we need to understand the role of bacteria and their metabolites in the activation of Th17 lymphocytes. We hypothesize that there is a closed cycle of stimulation between intestinal dysbiosis and Th17 lymphocytes in MS patients. We believe that both Th17 lymphocytes influence intestinal dysbiosis, and intestinal dysbiosis increases the activity of these immune cells.

Published on: April 22, 2019
doi: 10.17756/jnen.2019-051
Citation: de Souza Moreira BB, de Almeida Franzoi AE, Gonçalves MVM, do Nascimento OJM, Becker J, et al. 2019. Lymphocytes T Helper 17 in Multiple Sclerosis: Regulation by Intestinal Microbiota. J Neurol Exp Neurosci 5(1): 40-77.