Predictors of Development of Juvenile Multiple Sclerosis in Kazakh Population According to the DR-Genes of Major Histocompatibility Complex

JNEN-18M-066_40 Figure
Zhannat Idrissova, Meirbek Kolbaev, Aigerim Galym and Margarita Boldyreva
 

Abstract

The genetic factors associated with multiple sclerosis in Kazakhstan are not well understood. The aim of the study was to determine a major histocompatibility complex (MHC) genotype pattern and its clinical correlations in pediatric demyelinating diseases of multiple sclerosis (MS) spectrum in Kazakh population. For that a complex clinical, neuroimaging and immunogenetic examination was performed in 19 children (11 girls, 8 boys) with central nervous system (CNS) demyelination aged from 4 to 18 years. Clinically, 4 out of 19 children had leukoencephalitis (21%), and in 15 of 19 patients had MS (79%) including 6 presented with a clinically isolated syndrome. We found that presence of gene allele DRB1*15(02) and the associated alleles, combined in the haplotype DRB1*15(02)∼DQA1*01:02∼DQB1*06:02 point out a significantly higher risk of MS development, i.e. 7.7 fold in children and adolescents of the Kazakh ethnicity and a 3.12 fold risk for children of Russian ethnicity. We observed that presence of both DRB1*15 alleles (homozygotes) and of one DRB1*15 allele in combination with DRB1*03 in female teenagers presented with more aggressive “classical” MS; this aspect requires more profound clinical observations in a bigger cohort.

Published on: October 10, 2018
doi: 10.17756/jnen.2018-040
Citation: Idrissova Z, Kolbaev M, Galym A, Boldyreva M. 2018. Predictors of Development of Juvenile Multiple Sclerosis in Kazakh Population According to the DR-Genes of Major Histocompatibility Complex. J Neurol Exp Neurosci 4(2): 30-35.
 
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